The Significances of Bone Morphogenetic Protein (bmp-2) Expressionfor Predicting the Prognosis of Malignant Fibrous Histiocytoma (mfh)

Introduction Malignant fibrous histiocytoma(MFH) is clinically most frequently diagnosed in adult’s soft tissue sarcoma. And not only in soft tissue but also rarely in the bone or organ parenchyma that’s ocurrece has been reported. But because of treatments such as chemotherapies for MFH shows little effect so far, MFH’s prognosis has still not getting remarkable improvement. And it’s pivotal prognosis determing factor still remains unclear, too. While in osteosarcoma(OS), the relation between it’s prognosis and expression of bone morphogenetic protein-2 (BMP-2) has been studied in many researches. Some researchers reported that in proportion to increasing of it’s BMP-2 expression rate, it’s clinical courses are getting worse. Recently in MFH, BMP-2 expression has detected too. So we hypothesed that in BMP-2 detected in MFH, there are some correlation to it’s prognosis like OS.